Time Varying Apparent Volume of Distribution and Drug Half-Lives Following Intravenous Bolus Injections
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چکیده
منابع مشابه
Time Varying Apparent Volume of Distribution and Drug Half-Lives Following Intravenous Bolus Injections
We present a model that generalizes the apparent volume of distribution and half-life as functions of time following intravenous bolus injection. This generalized model defines a time varying apparent volume of drug distribution. The half-lives of drug remaining in the body vary in time and become longer as time elapses, eventually converging to the terminal half-life. Two example fit models we...
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ژورنال
عنوان ژورنال: PLOS ONE
سال: 2016
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0158798